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The church is built over three crypts, the oldest dating probably from Carolingian times (8th–10th century).

Taken together, they are known to have contained at least 6,338 prophecies, as well as at least eleven annual calendars, all of them starting on 1 January and not, as is sometimes supposed, in March.

After his expulsion, Nostredame continued working, presumably still as an apothecary, and became famous for creating a "rose pill" that purportedly protected against the plague.

On his return in 1545, he assisted the prominent physician Louis Serre in his fight against a major plague outbreak in Marseille, and then tackled further outbreaks of disease on his own in Salon-de-Provence and in the regional capital, Aix-en-Provence.

He was expelled shortly afterwards by the student procurator, Guillaume Rondelet, when it was discovered that he had been an apothecary, a "manual trade" expressly banned by the university statutes, and had been slandering doctors.

However, some of his publishers and correspondents would later call him "Doctor".